Self destroying breast cancer gene

Scientists at Belfast’s Queens’s University have pioneered new gene technology that causes breast cancer cells to self-destruct this is done by miniscule gene transport system and delivers the gene directly into the breast cancer cells making them die.

Named Designer Bioimetic Vector (DBV) put a gene into a nanoparticle 400 times smaller that the width of human hair and allowing to be sent straight into breast cancer cells in the laboratory.

The work has been carried out with the help from the Breast Cancer Campaign in the International Journal of Pharmaceutics, revealed Dr. Helen McCarthy from the Queen’s School of Pharmacy, she added that a problem with gene therapy in the past has been the delivery system and this DBV with the iNOS has proved to be successful in killing cancer cells in the lab.

This would ideally be administered before radiotherapy and chemotherapy on patients that have metastatic breast cancer that has spread to the bones. Poisonous nitric oxide is produced and either kills the cells outright or making them more vulnerable to being destroyed by chemotherapy and this helps since it leave normal breast cells unaffected and you do not get the side effects of the current treatments. This needs more investigation but will tested in patients in as little as five years.

Dr. Lisa Wilde has stated that Gene therapy could potentially be an exciting avenue for treating cancer. The research shows that the deliver system of genes to tumour cells holds great promise.